Journal: PLoS ONE
Article Title: Quantitative Model of Cell Cycle Arrest and Cellular Senescence in Primary Human Fibroblasts
doi: 10.1371/journal.pone.0042150
Figure Lengend Snippet: Model fitting of different radiation doses and experimentally derived PDs. The data were fitted using the same parameter set for all radiation doses (differing only in the applied amount of irradiation time) applying the model described by Eq. 3a–d: a, MRC-5 fibroblast, different radiation doses 0, 0.5 and 20 Gy; b, WI-38 fibroblast, radiation doses 0, 2 and 15 Gy.
Article Snippet: Primary human fibroblasts MRC-5 (primary cells, Homo sapiens , 14 weeks gestation male, fibroblasts from normal lung, normal diploid karyotype), WI-38 (primary cells, Homo sapiens , 3 months gestation female, fibroblasts from normal lung, normal diploid karyotype) and BJ (primary cells, Homo sapiens , newborn male, fibroblasts from normal foreskin, normal diploid karyotype), IMR-90 (primary cells, Homo sapiens , fibroblasts from normal lung, normal diploid karyotype) were obtained from ATCC (LGC Standards GmbH, Wesel, Germany).
Techniques: Derivative Assay, Irradiation